SYNTHESIS OF ZINC, COBALT AND COPPER HYDROXY-CARBONATES FOR CREATION OF ELECTROCHEMICAL NON-ENZYMATIC GLUCOSE SENSOR

Non-enzymatic glucose sensors are promising for reusable electrochemical test systems because of their high sensitivity, fast response and ease of operation. A wide class of materials such as noble metal nanoparticles, composites based on carbon nanomaterials, and metal oxides are used to create non-enzymatic glucose sensors. The search for new materials for the creation of highly sensitive glucose sensors is an urgent task. In the present work a new sensor material promising for the creation of glucose biosensors is investigated. Zinc, cobalt and copper hydroxy-carbonates were synthesized by hydrothermal method at 120 ^oC and characterized by scanning electron microscopy, X-ray diffraction analysis, Raman spectroscopy and electrochemical methods. It is shown that the synthesized material exhibits high sensitivity to glucose (11.2 mA*mM-1*cm-2), wide sensitivity range, thermal stability and is promising for the development of non-enzymatic glucose biosensors. The limit of detection, evaluated by the magnitude of the electrochemical response when the glucose concentration was varied within the interval up to 0.5 mM, was 0.007 mM. The obtained material showed thermal stability up to 200 ^oC when heated in an oxidizing atmosphere, which is important for ensuring long-term stability of sensory characteristics.

1. Tamoghna Saha, Rafael Del Caño, Kuldeep Mahato, Ernesto De la Paz, Chuanrui Chen, Shichao Ding, Lu Yin and Joseph Wang (2023) Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Reviews 123, 12, 7854–7889. https://doi.org/10.1021/acs.chemrev.3c00078.

2. Yan Wang, You Wu and Yifeng Lei. (2023) Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors. Biomater. Sci., 11, 5727–5757. https://doi.org/10.1039/D3BM00409K.

3. Kermue Vasco Jarnda, Danqi Wang, Qurrat-Ul-Ain, Richmond Anaman, Varney Edwin Johnson, Garmai Prosperity Roberts, Pauline Sammumah Johnson, Bob Wisdom Jallawide Jr, Tianhan Kai, Ping Ding (2023) Recent advances in electrochemical non-enzymatic glucose sensor for the detection of glucose in tears and saliva: A Review. Sensors and Actuators A: Physical 363, 114778. https://doi.org/10.1016/j.sna.2023.114778.

4. Daria Di Filippo, Frédérique N. Sunstrum, Jawairia Umar Khan, Alec W. Welsh. (2023) Non-Invasive Glucose Sensing Technologies and Products: A Comprehensive Review for Researchers and Clinicians. Sensors, 23(22), 9130. https://doi.org/10.3390/s23229130.

5. Muthukumar Govindaraj, Ananya Srivastava, Magesh Kumar Muthukumaran, Pei-Chien Tsai, Yuan-Chung Lin, Bharathi Kannan Raja, Jerome Rajendran, Vinoth Kumar Ponnusamy, J Arockia Selvi. (2023) Current advancements and prospects of enzymatic and non-enzymatic electrochemical glucose sensors. International Journal of Biological Macromolecules 253(Part 2), 126680. https://doi.org/10.1016/j.ijbiomac.2023.126680.

6. Seyed Saman Nemati, Gholamreza Dehghan, Samaneh Rashtbari, Tran Nhat Tan, Alireza Khataee. (2023) Enzyme-based and enzyme-free metal-based glucose biosensors: Classification and recent advances. Microchemical Journal 19,109038. https://doi.org/10.1016/j.microc.2023.109038

7. Guati, Carlota, Gomez-Coma, Lucía, Fallanza, Marcos and Ortiz, Inmaculada. (2024) Progress on the influence of non-enzymatic electrodes characteristics on the response to glucose detection: a review (2016– 2022). Reviews in Chemical Engineering, 40, 123-148.https://doi.org/10.1515/revce-2022-0058

8. Kathryn E. Toghill, Richard G. Compton (2010) Electrochemical Non-enzymatic Glucose Sensors: A Perspective and an Evaluation, International Journal of Electrochemical Science,Volume 5, 9, 1246–1301. https://doi.org/10.1016/S1452-3981(23)15359-4.

9. Strakosas, X., Selberg, J., Pansodtee, P. et al. (2019) A non-enzymatic glucose sensor enabled by bioelectronic pH control. Sci Rep 9, 10844. https://doi.org/10.1038/s41598-019-46302-9.

10. Mauro Pasta, Fabio La Mantia, Yi Cui. (2010) Mechanism of glucose electrochemical oxidation on gold surface, Electrochimica Acta, 55, 20, 5561–5568.https://doi.org/10.1016/j.electacta.2010.04.069.

11. Naikoo Gowhar A., Salim Hiba, Hassan Israr U., Awan Tasbiha, Arshad Fareeha, Pedram Mona Z., Ahmed Waqar, Qurashi Ahsanulhaq. (2021) Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management. A Review Frontiers in Chemistry, 9. https://doi.org/10.3389/fchem.2021.748957.

12. Devesh K. Pathak, Hong Chul Moon. (2023) Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor. Materials & Design 234,112309. https://doi.org/10.1016/j.matdes.2023.112309.

13. Emil R. Mamleyev, Peter G. Weidler, Alexei Nefedov, Dorothée Vinga Szabó, Monsur Islam, Dario Mager and Jan G. Korvink (2021) ACS Applied Nano Materials 4, 12, 13747–13760.https://doi.org/10.1021/acsanm.1c03149.

14. He W., Huang Y. & Wu J. (2020) Enzyme-Free Glucose Biosensors Based on MoS2 Nanocomposites. Nanoscale Res Lett 15, 60. https://doi.org/10.1186/s11671-020-3285-3.

15. Alves J.F., Edwards H.G.M., Korsakov A., de Oliveira L.F.C. (2023) Revisiting the Raman Spectra of Carbonate Minerals. Minerals, 13, 1358. https://doi.org/10.3390/min13111358.

16. William Dufresne, Carson Rufledt, Craig P Marshall. Raman spectroscopy of the eight natural carbonate minerals of calcite structure. Journal of Raman Spectroscopy 49, 3, 1999–2007, 2018.https://doi.org/10.1002/jrs.5481.

17. Qiaohui Guo, Tingting Wu, Lijuan Liu, Yi He, Dong Liu, Tianyan You. (2020) Hierarchically porous NiCo2S4 nanowires anchored on flexible electrospun graphitic nanofiber for high-performance glucose biosensing. Journal of Alloys and Compounds 819, 153376. https://doi.org/10.1016/j.jallcom.2019.153376.

18. Kim S.G., Jun J., Kim Y.K., Kim J., Lee J.S., Jang J. (2020) Facile Synthesis of Co3O4 -Incorporated Multichannel Carbon Nanofibers for Electrochemical Applications. ACS Appl. Mater. Interfaces, 12, 20613– 20622. https://doi.org/10.1021/acsami.0c06254.

19. Mohammadpour-Haratbar A., Mohammadpour-Haratbar S., Zare Y., Rhee K.Y., Park S.-J. (2022) A Review on Non-Enzymatic Electrochemical Biosensors of Glucose Using Carbon Nanofiber Nanocomposites. Biosensors, 12, 1004. https://doi.org/10.3390/bios12111004.

20. Vuslat B. Juska, Martyn E. Pemble. (2020) A Critical Review of Electrochemical Glucose Sensing: Evolution of Biosensor Platforms Based on Advanced Nanosystems. Sensors 20, 6013. https://doi.org/10.3390/s20216013.